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Current methods for the detection of SNPs include the following:

1. SSO (Sequence Specific Oligonucleotide) Dot
2. SSO (Sequence Specific Oligonucleotide) Reverse Dot
3. SSP (ARMS): Sequence-Specific Primers (Amplification Refraction Mutatory System)
4. RFLP (Restriction Fragment Length Polymorphism)
5. SSCP (Single Strand Conformation Polymorphism)
6. Direct Sequencing
7. Reference Strand Conformational Analysis
8.   Gene Chip Microarray/Microarray Sequencing


The above methods are often intensive, expensive, time-consuming and imprecise. They are also frequently dictated by the availability of existing equipment platforms. More fundamentally existing tests are unable to determine what haplotypes an individual possesses (see above).


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Cell Analysis Ltd • The Innovation Centre • Innovation Way • York  YO10 5DG  United Kingdom  Tel: +44 (0) 1904 435261    Fax: +44 (0) 1904 435126