 |
 |
| Current methods for the detection of SNPs include the following:
| 1. |
SSO (Sequence Specific Oligonucleotide) Dot |
| 2. |
SSO (Sequence Specific Oligonucleotide) Reverse
Dot |
| 3. |
SSP (ARMS): Sequence-Specific Primers (Amplification Refraction Mutatory
System) |
| 4. |
RFLP (Restriction Fragment Length Polymorphism)
|
| 5. |
SSCP (Single Strand Conformation Polymorphism) |
| 6. |
Direct Sequencing |
| 7. |
Reference Strand Conformational Analysis |
| 8. |
Gene Chip Microarray/Microarray Sequencing |
|
The above methods are often intensive, expensive, time-consuming and imprecise.
They are also frequently dictated by the availability of existing equipment platforms.
More fundamentally existing tests are unable to determine what haplotypes an
individual possesses (see above).
|
