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Single nucleotide polymorphisms (SNPs) are often close enough together to permit simultaneous identification with a single DUPLEXER™ reagent. This is common in genes with multiple genetic defects which contribute to inherited diseases (e.g. Canavan Disease or von Willebrands disease). The below gel demonstrates detection of mutiple SNP's within Canavan's E285A / A305E.

Canavan E285A/A305E Gel showing induced
heteroduplexes

 
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Cell Analysis Ltd • The Innovation Centre • Innovation Way • York  YO10 5DG  United Kingdom  Tel: +44 (0) 1904 435261    Fax: +44 (0) 1904 435126